Antihyperlipidemic Activity of Purified Polyphenol Extracted from Water Lettuce (Pistia stratiotes) Leaf: An In Vitro Analysis

Obesity is a metabolic disorder disease and excessive fat accumulation. Synthetic antiobesity (antihyperlipidemic) drugs are considered to cause some side effects. Therefore, the investigation of novel agents, with less adverse effects, major challenge in future research, such as from plant extracts. Thus, this research aimed investigate antihyperlipidemic purified polyphenol water lettuce (Pistia stratiotes) extract. The was conducted using crude extracts lettuce. purification process performed by solid-phase extraction HyperSep Retain PEP cartridge. qualitative analysis bioactive compounds (flavonoid, alkaloid, terpenoid, tannin) quantitative lipase inhibition were laboratory. results showed that flavonoid, tannin increased after process, whereas triterpenoid reduced. stretching polymeric hydroxyl group (O–H) H-bonded at 3382.36 cm-1 (crude extract) 3399.25 (purified indicate present phenol enzyme also 37.50% 72.50% extract). compound extract potential agent agent.